Low-affinity Fcγ receptors, autoimmunity and infection
- 13 August 2009
- journal article
- review article
- Published by Cambridge University Press (CUP) in Expert Reviews in Molecular Medicine
- Vol. 11, e24
- https://doi.org/10.1017/s1462399409001161
Abstract
Low-affinity Fcγ receptors (FcγRs) mediate the effects of immunoglobulin G (IgG) antibodies on leukocytes, including recruitment to inflammatory lesions, phagocytosis, antibody-dependent cellular cytotoxicity, release of inflammatory mediators and regulation of B cell activation. These functions are an important part of the mammalian response to infection, but if deployed inappropriately can cause autoimmune disease. Although most FcγRs are activatory, there is also an inhibitory FcγR that, when bound to IgG immune complexes, is able to downregulate the effects of both the activatory FcγRs and the B cell receptor. This review discusses the role of the low-affinity FcγRs in a balanced immune response and how perturbations in FcγR function result in susceptibility to infection or autoimmunity.Keywords
This publication has 144 references indexed in Scilit:
- An integrated approach for measuring copy number variation at theFCGR3(CD16) locusHuman Mutation, 2009
- Structural recognition and functional activation of FcγR by innate pentraxinsNature, 2008
- Molecular mimicry in pauci-immune focal necrotizing glomerulonephritisNature Medicine, 2008
- Nature and functions of autoantibodiesNature Clinical Practice Rheumatology, 2008
- TNFα blockade in human diseases: Mechanisms and future directionsClinical Immunology, 2008
- FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunityNature Genetics, 2007
- Systemic lupus erythematosus-associated defects in the inhibitory receptor FcγRIIb reduce susceptibility to malariaProceedings of the National Academy of Sciences of the United States of America, 2007
- Global variation in copy number in the human genomeNature, 2006
- Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humansNature, 2006
- Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibilityArthritis & Rheumatism, 2002