FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
- 21 May 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 39 (6), 721-723
- https://doi.org/10.1038/ng2046
Abstract
Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 × 10−8), microscopic polyangiitis (P = 2.9 × 10−4) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 × 10−3) and France (P = 1.1 × 10−4). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.Keywords
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