The association between celiac disease and eosinophilic esophagitis in children and adults
Open Access
- 30 May 2013
- journal article
- Published by Springer Science and Business Media LLC in BMC Gastroenterology
- Vol. 13 (1), 96
- https://doi.org/10.1186/1471-230x-13-96
Abstract
Background An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases. Methods All patients in a large Canadian city diagnosed with EoE or CD over a five-year period were identified. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated. Results Over the five-year study EoE was diagnosed in 421 patients and CD was diagnosed in 763 patients. The incidence of EoE ranged from 2.1 to 10.7 cases per 100,000 population. The incidence of CD ranged from 10.4 to 15.7 cases per 100,000 population. Among the EoE cohort, 83 (20%) cases of EoE and 245 (32%) cases of CD were diagnosed in pediatric patients. The incidence of EoE in the pediatric subpopulation ranged from 3.7 to 6.9 cases per 100,000 population. The incidence of CD in the pediatric subpopulation ranged from 9.5 to 22.7 cases per 100,000 population. The concomitant diagnosis of both EoE and CD was made in three patients, all of whom were pediatric males. The SIR for EoE in the CD cohort was 48.4 (95% CI = 9.73, 141.41) with a SIR for CD within the paediatric EoE cohort of 75.05 (95% CI = 15.08, 219.28). Conclusions This study confirms the association between EoE and CD. However, this association may be limited to pediatrics where the risk of each condition is increased 50 to 75-fold in patients diagnosed with the alternative condition. The concomitant diagnosis of these conditions should be considered in pediatric patients with upper gastrointestinal symptoms.Keywords
This publication has 39 references indexed in Scilit:
- Increased Incidence of Eosinophilic Esophagitis in Children and Adults With Celiac DiseaseJournal of Clinical Gastroenterology, 2012
- Potential selective advantage mechanism for polymorphic genetics in Celiac DiseaseMedical Hypotheses, 2011
- Celiac Disease and Eosinophilic Esophagitis: A True AssociationJournal of Pediatric Gastroenterology and Nutrition, 2010
- Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, MinnesotaClinical Gastroenterology and Hepatology, 2009
- Eosinophilic esophagitis in children with celiac diseaseJournal of Gastroenterology and Hepatology, 2008
- Eosinophilic oesophagitis and coeliac disease: is it just a casual association?Gut, 2007
- The Canadian Celiac Health SurveyDigestive Diseases and Sciences, 2007
- Rapidly increasing prevalence of eosinophilic oesophagitis in Western AustraliaArchives of Disease in Childhood, 2006
- Eosinophilic esophagitisGastroenterology Clinics of North America, 2003
- Esophageal eosinophilia with dysphagiaDigestive Diseases and Sciences, 1993