Increased Incidence of Eosinophilic Esophagitis in Children and Adults With Celiac Disease
- 1 January 2012
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Clinical Gastroenterology
- Vol. 46 (1), e6-e11
- https://doi.org/10.1097/mcg.0b013e318221aefd
Abstract
Goals and Background Case series have suggested an association between eosinophilic esophagitis (EoE) and celiac disease (CD) in children. We analyzed a cohort of patients with CD to confirm this association in children, and determine whether it extends into adulthood. Methods A database of patients with CD was reviewed to determine the number of patients with comorbid diagnoses of EoE. Histopathology reports of esophageal biopsies were reviewed to identify all cases of increased esophageal eosinophilia. Cases of EoE were diagnosed if biopsies revealed ≥15 eosinophils per high power field and associated symptoms were present. Age-adjusted and sex-adjusted standardized incidence ratios (SIR) with corresponding 95% confidence intervals (CI) were calculated in comparison to published US population-derived incidence data. Results EoE was diagnosed in 4 children and 10 adults. EoE is more common compared with the general population; SIR for children was 35.6 (95% CI, 9.3-79.0) and for adults 13.1 (95% CI, 6.2-22.5). Overall, the age-adjusted and sex-adjusted SIR was 16.0 (95% CI, 8.7-25.5). Conclusions The incidence of EoE in our cohort of patients with CD was increased compared with the general population. Coexistent EoE should be considered in patients with CD who have persistent esophageal symptoms.Keywords
This publication has 34 references indexed in Scilit:
- Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999Journal of Allergy and Clinical Immunology, 2010
- Biology and Treatment of Eosinophilic EsophagitisGastroenterology, 2009
- Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, MinnesotaClinical Gastroenterology and Hepatology, 2009
- Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment: Sponsored by the American Gastroenterological Association (AGA) Institute and North American Society of Pediatric Gastroenterology, Hepatology, and NutritionGastroenterology, 2007
- Celiac DiseaseThe New England Journal of Medicine, 2007
- Rapidly increasing prevalence of eosinophilic oesophagitis in Western AustraliaArchives of Disease in Childhood, 2006
- Eosinophilic EsophagitisThe New England Journal of Medicine, 2004
- Seroprevalence, correlates, and characteristics of undetected coeliac disease in EnglandGut, 2003
- Prevalence of Celiac Disease in At-Risk and Not-At-Risk Groups in the United StatesArchives of Internal Medicine, 2003
- The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 childrenThe American Journal of Gastroenterology, 2000