Pharmaceutical interventions for mitigating an influenza pandemic: modeling the risks and health-economic impacts
- 1 December 2010
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Anti-infective Therapy
- Vol. 8 (12), 1431-1439
- https://doi.org/10.1586/eri.10.136
Abstract
Model-based analyses built on burden-of-disease and cost-effectiveness theory predict that pharmaceutical interventions may efficiently mitigate both the epidemiologic and economic impact of an influenza pandemic. Pharmaceutical interventions typically encompass the application of (pre)pandemic influenza vaccines, other vaccines (notably pneumococcal), antiviral treatments and other drug treatment (e.g., antibiotics to target potential complications of influenza). However, these models may be too limited to capture the full macro-economic impact of pandemic influenza. The aim of this article is to summarize current health-economic modeling approaches to recognize the strengths and weaknesses of these approaches, and to compare these with more recently proposed alternative methods. We conclude that it is useful, particularly for policy and planning purposes, to extend modeling concepts through the application of alternative approaches, including insurers' risk theories, human capital approaches and sectoral and full macro-economic modeling. This article builds on a roundtable meeting of the Pandemic Influenza Economic Impact Group that was held in Boston, MA, USA, in December 2008.Keywords
This publication has 40 references indexed in Scilit:
- The economy-wide impact of pandemic influenza on the UK: a computable general equilibrium modelling experimentBMJ, 2009
- Modelling mitigation strategies for pandemic (H1N1) 2009CMAJ : Canadian Medical Association Journal, 2009
- Economic Evaluation of Influenza Pandemic Mitigation Strategies in the United States Using a Stochastic Microsimulation Transmission ModelValue in Health, 2009
- Optimal allocation of pandemic influenza vaccine depends on age, risk and timingVaccine, 2008
- Cost-effectiveness of Antiviral Stockpiling and Near-Patient Testing for Potential Influenza PandemicEmerging Infectious Diseases, 2008
- The Macroeconomic Effects of a Pandemic in Europe - A Model-Based AssessmentSSRN Electronic Journal, 2006
- Pandemic Influenza and Healthcare Demand in the Netherlands: Scenario AnalysisEmerging Infectious Diseases, 2003
- The Economic Impact of Pandemic Influenza in the United States: Priorities for InterventionEmerging Infectious Diseases, 1999
- Economic Evaluation of Influenza VaccinationPharmacoEconomics, 1999
- Vaccination and herd immunity to infectious diseasesNature, 1985