Herpes Simplex Virus Infection Downmodulates NKG2D Ligand Expression
Open Access
- 8 April 2009
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 69 (5), 429-436
- https://doi.org/10.1111/j.1365-3083.2009.02241.x
Abstract
Herpes simplex virus (HSV) type 1 infection may cause orofacial infections in humans. The virus resides in a latent form in neural ganglia and occasionally reactivates and infects epithelial cells. Natural killer (NK) cells have been implicated in immune control of herpes virus infections, possibly by downmodulating major histocompatibility complex (MHC) class I and by other, as yet unidentified, mechanisms. Upon HSV-1 infection of cell lines, surface levels of NKG2D ligands MHC class I related proteins (MIC) A and UL16 binding protein 2 were downmodulated due to late viral gene product(s). As also MHC class I levels were reduced by HSV-1, NK cell recognition of HeLa cells was not affected by infection. Total cellular MICA contents remained unchanged, suggesting masking, internalization or intracellular retention of MICA as possible mechanisms of viral downregualtion of MICA surface levels. Furthermore, NK cells from patients with active HSV-1 infection had a tendency towards increased expression level of the activating receptor NKG2D. These data support a role for NKG2D–MICA interactions in immune responses to HSV-1 reactivation.This publication has 37 references indexed in Scilit:
- An Increase in Herpes Simplex Virus Type 1 in the Anterior Segment of the Eye Is Linked to a Deficiency in NK Cell Infiltration in Mice Deficient in CXCR3Journal of Interferon & Cytokine Research, 2008
- Evolutionary struggles between NK cells and virusesNature Reviews Immunology, 2008
- Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicityProceedings of the National Academy of Sciences, 2008
- Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptorsBlood, 2007
- Expression of ICP0 Is Sufficient to Trigger Natural Killer Cell Recognition of Herpes Simplex Virus–Infected Cells by Natural Cytotoxicity ReceptorsThe Journal of Infectious Diseases, 2007
- Herpes Simplex Virus Encephalitis in Human UNC-93B DeficiencyScience, 2006
- Recent Developments in the Management of Herpes Simplex Virus Infection in HIV‐Infected PersonsClinical Infectious Diseases, 2004
- Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0Journal of Virology, 2004
- Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICAScience, 1999
- Infected Cell Protein (ICP)47 Enhances Herpes Simplex Virus Neurovirulence by Blocking the CD8+ T Cell ResponseThe Journal of Experimental Medicine, 1998