Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
- 1 June 1988
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 333 (6175), 742-746
- https://doi.org/10.1038/333742a0
Abstract
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.Keywords
This publication has 22 references indexed in Scilit:
- T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigensNature, 1988
- Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complexNature, 1988
- Interaction between CD4 and class II MHC molecules mediates cell adhesionNature, 1987
- Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genesCell, 1987
- T cell tolerance by clonal elimination in the thymusCell, 1987
- The selection of the α,β heterodimeric T-cell receptor for antigenImmunology Today, 1986
- Transfer of specificity by murine α and β T-cell receptor genesNature, 1986
- The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.The Journal of Experimental Medicine, 1983
- Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.The Journal of Experimental Medicine, 1982
- Effects of cytotoxic monoclonal antibody specific for T200 glycoprotein on functional lymphoid cell populationsCellular Immunology, 1980