Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast
- 8 July 1993
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 364 (6433), 121-126
- https://doi.org/10.1038/364121a0
Abstract
A novel genetic selection in yeast has been used to isolate a complementary DNA for the transcriptional activator, Olf-1, which binds to the regulatory sequences of several olfactory-specific genes. The Olf-1 protein, expressed exclusively in the olfactory receptor neurons and their precursors, contains a new helix–loop–helix motif and functions as an apparent homodimer. Olf-1 may be the first member of a family of related proteins that may direct cellular differentiation in a variety of neuronal tissues.Keywords
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