The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
- 15 February 1991
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 251 (4995), 761-766
- https://doi.org/10.1126/science.1846704
Abstract
The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.This publication has 72 references indexed in Scilit:
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