Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus, South Korea, 2015
Open Access
- 1 February 2016
- journal article
- research article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 22 (2), 327-330
- https://doi.org/10.3201/eid2202.151700
Abstract
During the 2015 Middle East respiratory syndrome coronavirus outbreak in South Korea, we sequenced full viral genomes of strains isolated from 4 patients early and late during infection. Patients represented at least 4 generations of transmission. We found no evidence of changes in the evolutionary rate and no reason to suspect adaptive changes in viral proteins.Keywords
This publication has 15 references indexed in Scilit:
- Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence AnalysismBio, 2015
- Complete Genome Sequence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) from the First Imported MERS-CoV Case in ChinaMicrobiology Resource Announcements, 2015
- Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015Eurosurveillance, 2015
- Transmission of MERS-Coronavirus in Household ContactsNew England Journal of Medicine, 2014
- A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike ProteinJournal of Virology, 2014
- Human Infection with MERS Coronavirus after Exposure to Infected Camels, Saudi Arabia, 2013Emerging Infectious Diseases, 2014
- Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitorNature Communications, 2014
- Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic studyThe Lancet, 2013
- Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4Cell Research, 2013
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi ArabiaNew England Journal of Medicine, 2012