Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation
- 7 February 1986
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4738), 587-589
- https://doi.org/10.1126/science.3003904
Abstract
Protein kinase C activity in rat hippocampal membranes and cytosol was determined 1 minute and 1 hour after induction of the synaptic plasticity of long-term potentiation. At 1 hour after long-term potentiation, but not at 1 minute, protein kinase C activity was increased twofold in membranes and decreased proportionately in cytosol, suggesting translocation of the activity. This time-dependent redistribution of enzyme activity was directly related to the persistence of synaptic plasticity, suggesting a novel mechanism regulating the strength of synaptic transmission.Keywords
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