Multiple sclerosis, interferon beta and clinical thyroid dysfunction
- 12 February 2003
- journal article
- case report
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 107 (2), 154-157
- https://doi.org/10.1034/j.1600-0404.2003.02009.x
Abstract
The objective of this study was to investigate frequency and presentation of clinical thyroid dysfunction in patients treated with interferon beta (IFN‐β). We have collected the cases of clinical thyroid dysfunction in 700 consecutive patients receiving IFN‐β for multiple sclerosis (MS). Five patients (four women, one man) treated with IFN‐β1b developed hyperthyroidism. Three of them have secondary progressive MS, and two have relapsing–remitting MS. It was necessary to stop IFN‐β in three cases; these patients still require carbimazole after several months. In the two other cases, hyperthyroidism disappeared spontaneously. Two patients (one man and one woman) treated with IFN‐β1a developed hypothyroidism. One of them required l‐thyroxine. Lastly, an increased thyroid volume without modification of thyroid hormones plasma levels was discovered in a patient receiving IFN‐β1a. Among patients treated with IFN‐β, clinical thyroid dysfunction is much rarer than laboratory thyroid dysfunction. However, this side‐effect is sometimes severe.Keywords
This publication has 23 references indexed in Scilit:
- Liver and thyroid function and autoimmunity during interferon-β1b treatment for MSNeurology, 2001
- Long-term interferon β-1b therapy for MSNeurology, 2000
- Occurrence of thyroid autoimmunity in relapsing remitting multiple sclerosis patients undergoing interferon-β treatmentNeurological Sciences, 1998
- Interferon beta-1b injection site reactions and necrosesMultiple Sclerosis Journal, 1998
- Side effect profile of interferon beta-lb in MSNeurology, 1996
- Interferon beta‐lb in the treatment of multiple sclerosisNeurology, 1995
- Reversibility of thyroid dysfunction induced by recombinant alpha interferon in chronic hepatitis CClinical Endocrinology, 1993
- Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosisNeurology, 1993
- Thyroid dysfunction and liver injury following alpha-interferon treatment of chronic viral hepatitisDigestive Diseases and Sciences, 1991
- Multiple sclerosis and autoimmune diseasesNeurology, 1983