Occurrence of thyroid autoimmunity in relapsing remitting multiple sclerosis patients undergoing interferon-β treatment
- 1 April 1998
- journal article
- research article
- Published by Springer Science and Business Media LLC in The Italian Journal of Neurological Sciences
- Vol. 19 (2), 65-67
- https://doi.org/10.1007/bf02427558
Abstract
We analyzed the titer of antithyroid autoantibodies Abs) and thyroid function in 17 multiple sclerosis (MS) patients undergoing interferon-β (IFN-β) treatment and in 40 MS control patients. Basal evaluation revealed normal thyroid function in all patients. Abs were detected in 5 IFN-β-treated patients (29%) and in 4 MS control patients (10%). Our results indicate that IFN-β treatment may lead to thyroid autoimmunity. We therefore recommend periodic evaluations of antithyroid Abs and thyroid functionality in IFN-β-treated MS patients.Keywords
This publication has 16 references indexed in Scilit:
- Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 CellsThe Journal of Experimental Medicine, 1997
- Iodine-Induced Autoimmune Thyroiditis in NOD-H-2h4MiceClinical Immunology and Immunopathology, 1996
- Exacerbation of Thyroid Autoimmunity by Interferon .ALPHA. Treatment in Patients with Chronic Viral Hepatitis: Our Studies and Review of the Literature.Endocrine Journal, 1994
- Switch of CD8 T Cells to Noncytolytic CD8 - CD4 - Cells that Make T H 2 Cytokines and Help B CellsScience, 1993
- Human TH1 and TH2 subsets: doubt no moreImmunology Today, 1991
- Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.JCI Insight, 1991
- Multiple sclerosis and other immunologic diseasesActa Neurologica Scandinavica, 1990
- ANTITHYROID ANTIBODIES IN MULTIPLE SCLEROSISThe Lancet, 1980
- Multiple Sclerosis and Autoimmune DiseasesAustralian and New Zealand Journal of Medicine, 1972
- Immunological Studies in Multiple Sclerosis: Incidence of Circulating Antibodies to Dietary Proteins and Auto-antigensBMJ, 1965