Reduced Phase-Advance of Plasma Melatonin After Bright Morning Light in The Luteal, But Not Follicular, Menstrual Cycle Phase in Premenstrual Dysphoric Disorder: An Extended Study
- 1 May 2011
- journal article
- research article
- Published by Taylor & Francis Ltd in Chronobiology International
- Vol. 28 (5), 415-424
- https://doi.org/10.3109/07420528.2011.567365
Abstract
The authors previously observed blunted phase-shift responses to morning bright light in women with premenstrual dysphoric disorder (PMDD). The aim of this study was to determine if these findings could be replicated using a higher-intensity, shorter-duration light pulse and to compare these results with the effects of an evening bright-light pulse. In 17 PMDD patients and 14 normal control (NC) subjects, the authors measured plasma melatonin at 30-min intervals from 18:00 to 10:00 h in dim (<30 lux) or dark conditions the night before (Night 1) and after (Night 3) a bright-light pulse (administered on Night 2) in both follicular and luteal menstrual cycle phases. The bright light (either 3000 lux for 6 h or 6000 lux for 3 h) was given either in the morning (AM light), 7 h after the dim light melatonin onset (DLMO) measured the previous month, or in the evening (PM light), 3 h after the DLMO. In the luteal, but not in the follicular, phase, AM light advanced melatonin offset between Night 1 and Night 3 significantly less in PMDD than in NC subjects. The effects of PM light were not significant, nor were there significant effects of the light pulse on melatonin measures of onset, duration, peak, or area under the curve. These findings replicated the authors’ previous finding of a blunted phase-shift response to morning bright light in the luteal, but not the follicular, menstrual cycle phase in PMDD compared with NC women, using a brighter (6000 vs. 3000 lux) light pulse for a shorter duration (3 vs. 6 h). As the effect of PM bright light on melatonin phase-shift responses did not differ between groups or significantly alter other melatonin measures, these results suggest that in PMDD there is a luteal-phase subsensitivity or an increased resistance to morning bright-light cues that are critical in synchronizing human biological rhythms. The resulting circadian rhythm malsynchonization may contribute to the occurrence of luteal phase depressive symptoms in women with PMDD. (Author correspondence: bparry@ucsd.edu)Keywords
This publication has 30 references indexed in Scilit:
- ETHICS AND METHODS FOR BIOLOGICAL RHYTHM RESEARCH ON ANIMALS AND HUMAN BEINGSChronobiology International, 2010
- INCREASED SENSITIVITY TO LIGHT-INDUCED MELATONIN SUPPRESSION IN PREMENSTRUAL DYSPHORIC DISORDERChronobiology International, 2010
- Late, but not early, wake therapy reduces morning plasma melatonin: Relationship to mood in Premenstrual Dysphoric DisorderPsychiatry Research, 2008
- Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass IndexJournal of Clinical Endocrinology & Metabolism, 2008
- Circadian phase response curves to light in older and young women and menJournal of Circadian Rhythms, 2007
- Responsiveness of the aging circadian clock to lightNeurobiology of Aging, 2006
- The circadian basis of winter depressionProceedings of the National Academy of Sciences of the United States of America, 2006
- The Role of Central Serotonergic Dysfunction in the Aetiology of Premenstrual Dysphoric DisorderCNS Drugs, 2001
- Serotonin in the spotlightNature, 1997
- Do gonadal steroids regulate circadian rhythms in humans?Journal of Affective Disorders, 1993