Increased Melatonin and Delayed Offset in Menopausal Depression: Role of Years Past Menopause, Follicle-Stimulating Hormone, Sleep End Time, and Body Mass Index
Open Access
- 1 January 2008
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 93 (1), 54-60
- https://doi.org/10.1210/jc.2006-2853
Abstract
Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controls women (NC). Design: We measured plasma melatonin every 30 min from 1800–1000 h in dim light (Setting: The study was conducted at a university hospital. Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated. Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood. Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores. Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.Keywords
This publication has 36 references indexed in Scilit:
- Circadian Phase in Adults of Contrasting AgesChronobiology International, 2005
- Effect of Menopause on Melatonin and Alertness Rhythms Investigated in Constant Routine ConditionsChronobiology International, 2005
- A Longitudinal Evaluation of the Relationship Between Reproductive Status and Mood in Perimenopausal WomenAmerican Journal of Psychiatry, 2004
- Association of morning illumination and window covering with mood and sleep among post-menopausal womenSleep and Biological Rhythms, 2004
- Local Polynomial Regression Modeling of Human Plasma Melatonin LevelsJournal of Biological Rhythms, 2004
- Depression and endogenous melatonin in postmenopausal womenJournal of Affective Disorders, 2002
- Sleep complaints of postmenopausal womenClinical Journal of Woman's Health, 2001
- Menopause: The Aging of Multiple PacemakersScience, 1996
- Immediate and Delayed Effects of Bright Light on Human Melatonin Production: Shifting “Dawn” and “Dusk” Shifts the Dim Light Melatonin Onset (DLMO)aAnnals of the New York Academy of Sciences, 1985
- ABNORMAL 24 HOUR PATTERN OF MELATONIN SECRETION IN DEPRESSIONThe Lancet, 1979