Synthesis and Antimicrobial Evaluation of Some Arylhydrazones of 4‐[(2‐Methylimidazo[1,2‐a]pyridine‐3‐yl)azo]benzoic Acid Hydrazide
- 1 January 1990
- journal article
- Published by Wiley in Archiv der Pharmazie
- Vol. 323 (3), 141-144
- https://doi.org/10.1002/ardp.19903230304
Abstract
A short series of arylhydrazones of 4‐[(2‐methylimidazo[1,2‐a]pyridine‐3‐yl)azo]benzoic acid hydrazide was synthesized and tested for antimicrobial activity. All of the compounds show antimicrobial activity against Escherichia coli. A few members were also active against Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. The interplanar angle (θ) between the aryl ring and the adjacent azomethine group of some representative compounds was measured by electronic absorption spectroscopy. No structure‐activity‐relationship between interplanar angle or lipophily and activity was found. Synthese und antimikrobielle Wirksamkeit einiger Arylhydrazone von 4‐[(2‐methylimidazo[1,2‐a]pyridin‐3‐yl)azo]benzoesäurehydrazid Es wird über die Darstellung und die antimikrobielle Wirkung einiger Arylhydrazone von 4‐[(2‐methylimidazo[1,2‐a]pyridin‐3‐yl)azo]benzoesäurehydrazid berichtet. Alle Substanzen hemmen das Wachstum von Escherichia coli. Einige Verbindungen sind auch wirksam gegen Klebsiella pneumoniae, Staphylococcus aureus und Pseudomonas aeruginosa. Durch Elektronenabsorptionsspektrometrie wurde der interplanare Winkel (θ) zwischen dem Arylrest und benachbarten Azomethingruppe einiger representativer Substanzen bestimmt. Zwischen Interplanar‐Winkel bzw. Lipophilie und den Wirksamkeiten konnte keine Struktur‐Wirkungs‐Beziehungen festgestellt werden.Keywords
This publication has 6 references indexed in Scilit:
- Synthesis and Antimicrobial Activity of Novel Quinazolone DerivativesJournal of Pharmaceutical Sciences, 1984
- Substituted imidazo[1,2-a]pyridine-2-carbamate anthelminticsJournal of Medicinal Chemistry, 1981
- Estrogenic activity and steric hindrance to coplanarity of alkyl substituted 4,4′-dimethoxystilbenesCellular and Molecular Life Sciences, 1961
- Studies in light absorption. Part XI. Substituted benzaldehydes, acetophenones and related compounds. The effects of steric conformation on the electronic spectra of conjugated systemsJournal of the Chemical Society, 1955
- 278. Tuberculostatic hydrazides and their derivativesJournal of the Chemical Society, 1953
- Geometrical Isomers in a Series of AntihistaminesNature, 1951