Substituted imidazo[1,2-a]pyridine-2-carbamate anthelmintics
- 1 December 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (12), 1518-1521
- https://doi.org/10.1021/jm00144a030
Abstract
Anthelminthic efficacies of a series of 6-substituted methyl imidazo[1,2-a]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2a]-pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2a]pyridine-2-carbamate to be the most potent derivative in the series. Evaluation in sheep indicated that its anthelminthic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2a]pyridine-2-carbamate.This publication has 1 reference indexed in Scilit:
- Methyl 6-(phenylsulfinyl)imidazo[1,2-a]pyridine-2-carbamate, a potent, new anthelminticJournal of Medicinal Chemistry, 1978