GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
- 1 January 2010
- journal article
- Published by Genetics and Molecular Research in Evolution
- Vol. 9 (2), 1045-1053
- https://doi.org/10.4238/vol9-2gmr726
Abstract
The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1"null", GSTM1/GSTM1"null" and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant chemotherapy in the treatment of stage II and III breast cancer. Forty Brazilian women with invasive ductal adenocarcinoma of the breast submitted to neoadjuvant chemotherapy, using 5-fluorouracil, epirubicin and cyclophosphamide, were genotyped for the GSTT1, GSTM1 and GSTP1 genes. ClinicalKeywords
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