GLUTATHIONE CONJUGATES AND THEIR SYNTHETIC DERIVATIVES AS INHIBITORS OF GLUTATHIONE-DEPENDENT ENZYMES INVOLVED IN CANCER AND DRUG RESISTANCE
- 1 January 2002
- journal article
- review article
- Published by Informa UK Limited in Drug Metabolism Reviews
- Vol. 34 (4), 821-863
- https://doi.org/10.1081/dmr-120015695
Abstract
Alterations in levels of glutathione (GSH) and glutathione-dependent enzymes have been implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, the multidrug resistance-associated protein 1, glutathione S-transferase, DNA-dependent protein kinase, glyoxalase I, and gamma-glutamyl transpeptidase, can be inhibited by GSH-conjugates and synthetic analogs thereof. In this review we focus on the function of these enzymes and carriers in cancer and anti-cancer drug resistance, in relation to their inhibition by GSH-conjugate analogs.Keywords
This publication has 93 references indexed in Scilit:
- Induction of Multidrug Resistance Proteins MRP1 and MRP3 and γ-Glutamylcysteine Synthetase Gene Expression by Nonsteroidal Anti-inflammatory Drugs in Human Colon Cancer CellsBiochemical and Biophysical Research Communications, 2002
- Acivicin Induces Apoptosis Independently of γ-Glutamyltranspeptidase ActivityBiochemical and Biophysical Research Communications, 2001
- DNA-Dependent Protein Kinase Is Inhibited by TrifluoperazineBiochemical and Biophysical Research Communications, 2001
- α-Tocopherol Inhibits Human Glutathione S-Transferase πBiochemical and Biophysical Research Communications, 2001
- A Leukotriene Receptor Antagonist, ONO-1078, Modulates Drug Sensitivity and Leukotriene C4Efflux in Lung Cancer Cells Expressing Multidrug Resistance ProteinBiochemical and Biophysical Research Communications, 1998
- Biology of the multidrug resistance-associated protein, MRPEuropean Journal Of Cancer, 1996
- DNA-Dependent Protein Kinase Inhibitor (OK-1035) Suppresses p21 Expression in HCT116 Cells Containing Wild-Type p53 Induced by AdriamycinBiochemical and Biophysical Research Communications, 1996
- Adriamycin resistance in HL60 cells in the absence of detectable P-glycoproteinBiochemical and Biophysical Research Communications, 1987
- Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate bindingBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Glyoxalase inhibitors as potential anticancer agentsBiochemical and Biophysical Research Communications, 1969