Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer
Open Access
- 6 December 2005
- journal article
- case report
- Published by Springer Science and Business Media LLC in BMC Cancer
- Vol. 5 (1), 156-5
- https://doi.org/10.1186/1471-2407-5-156
Abstract
Background Zoledronic acid is very widely used in patients with metastatic bone disease and osteoporosis. Only one case of bilateral uveitis was recently reported related to its use. Case presentation We report the first case of severe unilateral anterior uveitis in a patient with breast cancer and an intraocular lens. Following zoledronic acid infusion, the patient developed severe and dramatic right eye pain with decreased visual acuity within 24 hours and was found to have a fibrinous anterior uveitis of moderate severity The patient was treated with topical prednisone and atropine eyedrops and recovered slowly over several months. Conclusion Internists, oncologists, endocrinologists, and ophtalmologists should be aware of uveitis as a possible complication of zoledronic acid therapy. Patients should be instructed to report immediately to their physicians and treatment with topical prednisone and atropine eyedrops should be instituted immediately at the onset of symptoms. This report documents anterior uveitis as a complication of zoledronic acid therapy. This reaction could be an idiosyncratic one but further research may shed more light on the etiology.Keywords
This publication has 13 references indexed in Scilit:
- Safety of Intravenous and Oral Bisphosphonates and Compliance With Dosing RegimensThe Oncologist, 2004
- Bilateral acute uveitis and conjunctivitis after zoledronic acid therapyEye, 2004
- A Randomized Trial of Letrozole in Postmenopausal Women after Five Years of Tamoxifen Therapy for Early-Stage Breast CancerNew England Journal of Medicine, 2003
- Bisphosphonates: new indications and methods of administrationCurrent Opinion in Rheumatology, 2003
- Clodronate induced uveitisAnnals Of The Rheumatic Diseases, 2003
- Scleritis and other ocular side effects associated with pamidronate disodiumAmerican Journal of Ophthalmology, 2003
- Bilateral acute anterior uveitis after alendronateBritish Journal of Ophthalmology, 2002
- Nongranulomatous anterior uveitis associated with alendronate therapy.2002
- Uveitis, an under-recognized adverse effect of pamidronate. Case report and literature review.2000
- The effects of diphosphonates on the exchangeable and non-exchangeable calcium and phosphate of hydroxyapatiteBiochimica et Biophysica Acta (BBA) - General Subjects, 1972