In April 2001 the patient presented with a three month history of spinal pain, following an accidental fall. Spine and pelvis x ray examination showed osteoporotic fractures in T12, L1, and L2 vertebral bodies. Bone densitometry dual energy x ray absorptiometry evaluation showed remarkably reduced mineral density in both vertebral and femoral neck sites (T score −4.3 and −4.08, respectively). Because the patient had had reflux oesophagitis, we treated her with 100 mg once a week of intramuscular (IM) clodronate, the only parenteral BP available for outpatients in our country. The treatment progressively reduced the spinal pain.