2,4-Toluene Diamines—Their Carcinogenicity, Biodegradation, Analytical Techniques and an Approach towards Development of Biosensors
- 2 December 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Analytical Sciences
- Vol. 17 (12), 1369-1374
- https://doi.org/10.2116/analsci.17.1369
Abstract
2,4-Toluene diamine (TDA), a class A carcinogen, is a major raw material for the production of toluene diisocyanate (TDI), which is one of the precursors for the production of polyurethane foams (PU). This review deals with 2,4-toluene diamine's (TDA) carcinogenicity, analytical techniques, biodegradation and use as a biosensor for biogenic and synthetic amines, emphasizing various carcinogenicity studies by 2,4-TDA on animals and humans. This review reports some publications of the analysis of body fluid samples of workers from a PU producing factory for presence of TDA and TDI, since TDI gets absorbed into the worker's body, getting metabolized into TDA. Biodegradations of 2,4-TDA by various researchers are reported and also our own research experience with biodegradation of 2,4-TDA using Aspergillus nidulans isolated from soil site at a polyurethane foam dumping site have been discussed in this review. Biosensors for various biogenic and synthetic amines are discussed.Keywords
This publication has 41 references indexed in Scilit:
- Amine oxidase-based flow biosensor for the assessment of fish freshnessFood Control, 2000
- Determination of biogenic amines with an electrochemical biosensor and its application to salted anchoviesFood Chemistry, 1998
- Development of a diamine biosensorTalanta, 1997
- Interaction with the Aromatic Hydrocarbon Receptor, CYP1A Induction, and Mutagenicity of a Series of Diaminotoluenes: Implications for Their CarcinogenicityToxicology and Applied Pharmacology, 1996
- Aerobic biodegradation of 2,4-dinitrotoluene, aminonitrotoluene isomers, and 2,4-diaminotolueneJournal of Hazardous Materials, 1996
- The Polyurethane Foam Covering the Même Breast Prosthesis: A Biomedical Breakthrough or a Biomaterial Tar Baby?Annals of Plastic Surgery, 1992
- Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen: Carcinogen pair—2,6- and 2,4-diaminotolueneToxicology and Applied Pharmacology, 1991
- Toxic hydrolysis product from a biodegradable foam implantJournal of Biomedical Materials Research, 1989
- Covalent binding to DNA and mutagenicity of 2,4-diaminotoluene metabolites produced by isolated hepatocytes and 9000 g supernatant from Fischer 344 ratsCarcinogenesis: Integrative Cancer Research, 1987
- Determination of 2,4- and 2,6-diaminotoluene in flexible urethane foamsAnalytical Chemistry, 1977