Retracted: Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in growth hormone treated animals
- 23 May 2005
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 579 (14), 3152-3158
- https://doi.org/10.1016/j.febslet.2005.04.075
Abstract
In this study, we demonstrate that pretreatment with aspirin inhibits GH-induced insulin resistance. GH was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in liver, muscle and WAT in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation in the IR/IRSIPI(3)kinase pathway and a reduction in IRS-1 protein levels in rats treated with GH, which was also reversed in the animals pretreated with aspirin. Overall, these results provide new insights into the mechanism of GH-induced insulin resistance. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.Keywords
This publication has 38 references indexed in Scilit:
- Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic ratsBiochemical and Biophysical Research Communications, 2004
- Phosphoinositide 3-Kinase-mediated Reduction of Insulin Receptor Substrate-1/2 Protein Expression via Different Mechanisms Contributes to the Insulin-induced Desensitization of Its Signaling Pathways in L6 Muscle CellsPublished by Elsevier BV ,2003
- Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 PhosphorylationPublished by Elsevier BV ,2003
- c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling CascadePublished by Elsevier BV ,2003
- Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) CellsPublished by Elsevier BV ,2003
- A central role for JNK in obesity and insulin resistanceNature, 2002
- MAP Kinase Signaling SpecificityScience, 2002
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001
- Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of IkkβScience, 2001
- Prevention of fat-induced insulin resistance by salicylateJCI Insight, 2001