Noise Limits of CMOS Current Interfaces for Biosensors: A Review
Top Cited Papers
- 21 June 2013
- journal article
- research article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Biomedical Circuits and Systems
- Vol. 8 (2), 278-292
- https://doi.org/10.1109/tbcas.2013.2262998
Abstract
Current sensing readout is one of the most frequent techniques used in biosensing due to the charge-transfer phenomena occurring at solid-liquid interfaces. The development of novel nanodevices for biosensing determines new challenges for electronic interface design based on current sensing, especially when compact and efficient arrays need to be organized, such as in recent trends of rapid label-free electronic detection of DNA synthesis. This paper will review the basic noise limitations of current sensing interfaces with particular emphasis on integrated CMOS technology. Starting from the basic theory, the paper presents, investigates and compares charge-sensitive amplifier architectures used in both continuous-time and discrete-time approaches, along with their design trade-offs involving noise floor, sensitivity to stray capacitance and bandwidth. The ultimate goal of this review is providing analog designers with helpful design rules and analytical tools. Also, in order to present a comprehensive overview of the state-of-the-art, the most relevant papers recently appeared in the literature about this topic are discussed and compared.Keywords
Funding Information
- EC Seventh Framework Programme (FP7/2007-2013)
- ENIAC END
This publication has 65 references indexed in Scilit:
- Clock Jitter Effects on Sampling: A TutorialIEEE Circuits and Systems Magazine, 2011
- A dual analyzer for real-time impedance and noise spectroscopy of nanoscale devicesReview of Scientific Instruments, 2011
- A 32-$\mu$W 1.83-kS/s Carbon Nanotube Chemical Sensor SystemIEEE Journal of Solid-State Circuits, 2009
- Miniaturized planar lipid bilayer: increased stability, low electric noise and fast fluid perfusionAnalytical and Bioanalytical Chemistry, 2007
- Label-free immunodetection with CMOS-compatible semiconducting nanowiresNature, 2007
- Noise in Silicon NanowiresIEEE Transactions on Nanotechnology, 2006
- Microchip Technology in Ion-Channel ResearchIEEE Transactions on Nanobioscience, 2005
- Understanding Delta-Sigma Data ConvertersPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2004
- Microfabricated Teflon Membranes for Low-Noise Recordings of Ion Channels in Planar Lipid BilayersBiophysical Journal, 2003
- Noise analysis of switched capacitor networksIEEE Transactions on Circuits and Systems, 1983