Use of electrospray mass spectrometry to investigate the inhibition of β-lactamases by 6-halogenopenicillanic acids
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 121-123
- https://doi.org/10.1039/c39930000121
Abstract
Electrospray mass spectrometry has been used to investigate the mechanism of inhibition of class A and C β-lactamases by 6-halogenopenicillanic acids; in the case of the 6β-halogen substituted penicillanic acids the molecular mass differences observed between the unreacted and the inhibited β-lactamases are consistent with the formation of an enzyme bound dihydrothiazine derivative, as previously proposed.Keywords
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