Antioxidant and Antiproliferative Activities of Strawberries
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- 7 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 51 (23), 6887-6892
- https://doi.org/10.1021/jf034506n
Abstract
Strawberries contain high levels of antioxidants, which have been correlated with a decreased risk of chronic disease. To more fully characterize the antioxidant profiles and possible associated health benefits of this fruit, the total free and bound phenolic, total flavonoid, and total anthocyanin contents of eight strawberry cultivars (Earliglow, Annapolis, Evangeline, Allstar, Sable, Sparkle, Jewel, and Mesabi) were measured. Cultivar effects on phenolic contents were compared with antioxidant capacities, as measured by the total oxyradical scavenging capacity (TOSC) assay, and to anti proliferative activities, as measured by inhibition of HepG(2) human liver cancer cell proliferation in vitro. Free phenolic contents differed by 65% between the highest (Earliglow) and the lowest (Allstar) ranked cultivars. The water soluble bound and ethyl acetate soluble bound phenolic contents averaged 5% of the total phenolic content of the cultivars. The total flavonoid content of Annapolis was 2-fold higher than that of Allstar, which had the lowest content. The anthocyanin content of the highest ranked cultivar, Evangeline, was more than double that of the lowest ranked cultivar, Allstar. Overall, free phenolic content was weakly correlated with total antioxidant activity, and flavonoid and anthocyanin content did not correlate with total antioxidant activity. The proliferation of HepG2 human liver cancer cells was significantly inhibited in a dose-dependent manner after exposure to all strawberry cultivar extracts, with Earliglow exhibiting the highest antiproliferative activity and Annapolis exhibiting the lowest. No relationship was found between antiproliferative activity and antioxidant content.Keywords
This publication has 23 references indexed in Scilit:
- Antioxidant Activity of Apple PeelsJournal of Agricultural and Food Chemistry, 2003
- Antioxidant and Antiproliferative Activities of Common FruitsJournal of Agricultural and Food Chemistry, 2002
- Antioxidant and Antiproliferative Activities of Common VegetablesJournal of Agricultural and Food Chemistry, 2002
- Balancing Life-Style and Genomics Research for Disease PreventionScience, 2002
- Content of flavonols and selected phenolic acids in strawberries and Vaccinium species: influence of cultivar, cultivation site and techniqueFood Research International, 2000
- [15] Size separation of condensed tannins by normal-phase high-performance liquid chromatographyPublished by Elsevier BV ,1999
- Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidationJournal of Agricultural and Food Chemistry, 1998
- Oxidative DNA Damage Levels in Blood from Women at High Risk for Breast Cancer are Associated with Dietary intakes of Meats, Vegetables, and FruitsJournal of the American Dietetic Association, 1998
- Anthocyanin Composition of Red Raspberry Juice: Influences of Cultivar, Processing, and Environmental FactorsJournal of Food Science, 1993
- Radical Scavenging by Flavonoid AntioxidantsFree Radical Research Communications, 1987