Taurine and inflammatory diseases
Top Cited Papers
Open Access
- 19 July 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Amino Acids
- Vol. 46 (1), 7-20
- https://doi.org/10.1007/s00726-012-1361-4
Abstract
Taurine (2-aminoethanesulfonic acid) is the most abundant free amino acid in humans and plays an important role in several essential biological processes such as bile acid conjugation, maintenance of calcium homeostasis, osmoregulation and membrane stabilization. Moreover, attenuation of apoptosis and its antioxidant activity seem to be crucial for the cytoprotective effects of taurine. Although these properties are not tissue specific, taurine reaches particularly high concentrations in tissues exposed to elevated levels of oxidants (e.g., inflammatory cells). It suggests that taurine may play an important role in inflammation associated with oxidative stress. Indeed, at the site of inflammation, taurine is known to react with and detoxify hypochlorous acid generated by the neutrophil myeloperoxidase (MPO)–halide system. This reaction results in the formation of less toxic taurine chloramine (TauCl). Both haloamines, TauCl and taurine bromamine (TauBr), the product of taurine reaction with hypobromous acid (HOBr), exert antimicrobial and anti-inflammatory properties. In contrast to a well-documented regulatory role of taurine and taurine haloamines (TauCl, TauBr) in acute inflammation, their role in the pathogenesis of inflammatory diseases is not clear. This review summarizes our current knowledge concerning the role of taurine, TauCl and TauBr in the pathogenesis of inflammatory diseases initiated or propagated by MPO-derived oxidants. The aim of this paper is to show links between inflammation, neutrophils, MPO, oxidative stress and taurine. We will discuss the possible contribution of taurine and taurine haloamines to the pathogenesis of inflammatory diseases, especially in the best studied example of rheumatoid arthritis.Keywords
This publication has 101 references indexed in Scilit:
- Antimicrobial and Anticoagulant Activities of N -Chlorotaurine, N , N -Dichloro-2,2-Dimethyltaurine, and N -Monochloro-2,2-Dimethyltaurine in Human BloodAntimicrobial Agents and Chemotherapy, 2012
- Comparison of rheumatoid articular adipose and synovial tissue reactivity to proinflammatory stimuli: contribution to adipocytokine networkAnnals Of The Rheumatic Diseases, 2011
- The association between rheumatoid arthritis and periodontal diseaseArthritis Research & Therapy, 2010
- Innate Immunity and Rheumatoid ArthritisRheumatic Disease Clinics of North America, 2010
- Effect of taurine chloramine on the production of matrix metalloproteinases (MMPs) in adiponectin- or IL-1β-stimulated fibroblast-like synoviocytesJournal of Biomedical Science, 2010
- Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritisImmunological Reviews, 2009
- Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophilsProceedings of the National Academy of Sciences of the United States of America, 2009
- Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen PeroxideJournal of Clinical Biochemistry and Nutrition, 2009
- Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1β stimulated fibroblast-like synoviocytesArthritis Research & Therapy, 2007
- The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritisArthritis & Rheumatism, 1987