Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis
Top Cited Papers
- 23 December 2009
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 233 (1), 233-255
- https://doi.org/10.1111/j.0105-2896.2009.00859.x
Abstract
Summary: Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant therapeutic advances. The pathogenesis of RA is complex and includes many cell types, including T cells, B cells, and macrophages. Fibroblast‐like synoviocytes (FLS) in the synovial intimal lining also play a key role by producing cytokines that perpetuate inflammation and proteases that contribute to cartilage destruction. Rheumatoid FLS develop a unique aggressive phenotype that increases invasiveness into the extracellular matrix and further exacerbates joint damage. Recent advances in understanding the biology of FLS, including their regulation regulate innate immune responses and activation of intracellular signaling mechanisms that control their behavior, provide novel insights into disease mechanisms. New agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses.Keywords
This publication has 137 references indexed in Scilit:
- Gadd45β deficiency in rheumatoid arthritis: Enhanced synovitis through JNK signalingArthritis & Rheumatism, 2009
- Regulation of the Hyaluronan Synthase 2 Gene by Convergence in Cyclic AMP Response Element-binding Protein and Retinoid Acid Receptor SignalingOnline Journal of Public Health Informatics, 2009
- Cell death in rheumatoid arthritisApoptosis, 2009
- Evidence that cytokines play a role in rheumatoid arthritisJCI Insight, 2008
- Synergistic benefit in inflammatory arthritis by targeting IκB kinase ϵ and interferon βAnnals Of The Rheumatic Diseases, 2008
- Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammationRheumatology, 2008
- The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2007
- Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblastsProceedings of the National Academy of Sciences of the United States of America, 2007
- Evolving concepts of rheumatoid arthritisNature, 2003
- Monoclonal expansion of synoviocytes in rheumatoid arthritisArthritis & Rheumatism, 1998