Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans
Open Access
- 25 July 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 52 (10), 2169-2181
- https://doi.org/10.1007/s00125-009-1451-3
Abstract
TNF-α levels are increased in obesity and type 2 diabetes. The regulation of TNF-α converting enzyme (TACE) and its inhibitor, tissue inhibitor of metalloproteinase 3 (TIMP3), in human type 2 diabetes is unknown.Keywords
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