The Relationship of Body Composition and Coronary Artery Calcification in Apparently Healthy Korean Adults
Open Access
- 1 January 2013
- journal article
- Published by Korean Endocrine Society in Endocrinology and Metabolism
- Vol. 28 (1), 33-40
- https://doi.org/10.3803/enm.2013.28.1.33
Abstract
We investigated the association of coronary artery calcium score (CACS) with body composition and insulin resistance in apparently healthy Korean adults. Nine hundred forty-five participants (mean age, 48.9 years; 628 men) in a medical check-up program were selected for analysis. Body composition was assessed by bioelectrical impedance analysis (BIA). Insulin resistance was evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). The CACS was assessed by multidetector computed tomography. One hundred forty-six subjects (15.4%) showed coronary artery calcification and 148 subjects (15.7%) had metabolic syndrome. CACS showed a significant positive correlation with age, fasting glucose level, waist circumference (WC), blood pressure, hemoglobin A1c, HOMA-IR, and waist-hip ratio (WHR) assessed by BIA. CACS had a negative correlation with high density lipoprotein cholesterol (HDL-C). Subjects with high CACS showed significantly higher mean WHRs and lower mean values for lean body mass compared with subjects without coronary artery calcification. In logistic regression analyses with coronary artery calcification as the dependent variable, the highest quartile of WHR showed a 3.125-fold increased odds ratio for coronary artery calcification compared with the lowest quartile after adjustment for confounding variables. When receiver operating characteristics analyses were performed with coronary artery calcification as the result variable, WHR showed the largest area under the curve (AUC) value among other variables except for age and WC in women (AUC=0.696 for WHR, 0.790 for age, and 0.719 for WC in women). In our study population of apparently healthy Korean adults, WHR was the most significant predictor for coronary artery calcification among other confounding factors, suggesting that it may have implication as a marker for early atherosclerosis.Keywords
This publication has 19 references indexed in Scilit:
- Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: The Jackson Heart StudyAtherosclerosis, 2012
- Role of Nonenhanced Multidetector CT Coronary Artery Calcium Testing in Asymptomatic and Symptomatic IndividualsRadiology, 2012
- Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patientsAtherosclerosis, 2009
- Visceral obesity and the heartThe International Journal of Biochemistry & Cell Biology, 2008
- Abdominal obesity and coronary artery calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) StudyThe American Journal of Clinical Nutrition, 2007
- Associations between Aortic Calcification and Components of Body Composition in Elderly MenObesity, 2006
- May subclinical arterial disease help to better detect and treat high-risk asymptomatic individuals?Journal of Hypertension, 2005
- Coronary Artery Calcium Score Combined With Framingham Score for Risk Prediction in Asymptomatic IndividualsPublished by American Medical Association (AMA) ,2004
- Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseasesJournal of Physiology and Biochemistry, 2003
- Association of Multiple Risk Factors and Insulin Resistance With Increased Prevalence of Asymptomatic Coronary Artery Disease by an Electron-Beam Computed Tomographic StudyArteriosclerosis, Thrombosis, and Vascular Biology, 2001