Associations between Aortic Calcification and Components of Body Composition in Elderly Men
- 6 September 2006
- Vol. 14 (9), 1571-1578
- https://doi.org/10.1038/oby.2006.181
Abstract
To investigate associations among body composition, cardiovascular risk factors, and atherosclerosis in middle-aged and elderly men for the identification of potential pathogenic links. The study included 168 white men 44 to 86 years old. Severity of aortic calcification (AC) was graded on lateral radiographs, and body fat and lean mass were measured by DXA. Information on demographic and lifestyle characteristics also was gathered. A strong and independent inverse association was found between AC and peripheral lean mass (PLM), even after adjusting for age and BMI (p < 0.05). Independently of the influence of PLM, AC was directly correlated with truncal fat mass (p < 0.05). Furthermore, AC was inversely associated with tertiles of the free androgen index (p < 0.05). In a multiple regression model, age and serum cholesterol (p < 0.01) contributed directly, and truncal fat mass tended also to contribute directly (p = 0.09), whereas PLM contributed borderline inversely (p = 0.06) to the variation of AC (R = 0.635, p < 0.0001). Severity of AC is strongly dependent on age and further modulated by an array of traditional cardiovascular risk factors. Sarcopenia and truncal fat mass are reciprocal correlates of atherosclerosis of borderline statistical significance in multivariate models. To clarify whether sarcopenia is an atherogenic risk factor or rather a parallel consequence of low-grade inflammation also promoting atherogenic trends, further longitudinal studies in larger sample sizes of men and women are needed.Keywords
This publication has 26 references indexed in Scilit:
- The metabolic syndrome and inflammation: association or causation?Nutrition, Metabolism and Cardiovascular Diseases, 2004
- The aging male: testosterone deficiency and testosterone replacement. An up-dateAtherosclerosis, 2004
- Catabolism of aging: is it an inflammatory process?Current Opinion in Clinical Nutrition and Metabolic Care, 2003
- Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose TissueCirculation, 2003
- Inflammation in atherosclerosisNature, 2002
- The prediction of visceral fat by dual-energy X-ray absorptiometry in the elderly: a comparison with computed tomography and anthropometryInternational Journal of Obesity, 2002
- New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up studyAtherosclerosis, 1997
- Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosteroneJournal of Clinical Endocrinology & Metabolism, 1996
- Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgensJournal of Clinical Endocrinology & Metabolism, 1995
- Validation of body composition by dual energy X‐ray absorptiometry (DEXA)Clinical Physiology and Functional Imaging, 1991