The Effect of Pre-operative Lornoxicam and Ketoprofen Application on the Morphine Consumption of Post-operative Patient-controlled Analgesia
- 1 March 2006
- journal article
- research article
- Published by SAGE Publications in Journal of International Medical Research
- Vol. 34 (2), 168-175
- https://doi.org/10.1177/147323000603400206
Abstract
We compared the efficacy of preoperative intramuscular lornoxicam and ketoprofen for post-operative analgesia in patients undergoing abdominal hysterectomy. This randomized, double-blind, placebo-controlled, parallel-group study investigated 60 patients who received lornoxicam (group L, 8 mg), ketoprofen (group K, 100 mg) or saline (group C) 60 min before standard anaesthesia. All patients received patient-controlled analgesia (intravenous morphine) during the post-operative period. Visual analogue scale (VAS) scores recorded 2, 4, 6 and 12 h after surgery in groups L and K patients were significantly lower than in group C patients, and VAS scores at 2, 4 and 6 h in group L patients were significantly lower than those in group K patients. Morphine consumption in groups L and K was significantly lower than in group C. Pre-emptive administration of lornoxicam and ketoprofen effectively reduced post-operative pain and morphine consumption, and lornoxicam was more effective than ketoprofen in the early post-operative period.Keywords
This publication has 17 references indexed in Scilit:
- The preoperative administration of ketoprofen improves analgesia after laparoscopic cholecystectomy in comparison with propacetamol or postoperative ketoprofenBritish Journal of Anaesthesia, 2004
- Coptidis Rhizoma: protective effects against peroxynitrite-induced oxidative damage and elucidation of its active componentsJournal of Pharmacy and Pharmacology, 2004
- Lornoxicam bei gynäkologischen EingriffenDer Schmerz, 2003
- Multimodal analgesia for postoperative pain controlJournal of Clinical Anesthesia, 2001
- Randomised, placebo‐controlled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgeryActa Anaesthesiologica Scandinavica, 2000
- Randomisierte, doppelblinde Studie mit Ketoprofen bei gynäkologischen EingriffenDer Anaesthesist, 1998
- Zur präemptiven Wirkung von KetoprofenDer Anaesthesist, 1997
- Balanced analgesia improves recovery and outcome after outpatient tubal ligationActa Anaesthesiologica Scandinavica, 1996
- Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central SensitizationAnesthesia & Analgesia, 1993
- Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidencePain, 1993