Blockade of IL-6 Secretion Pathway by the Sesquiterpenoid Atractylenolide III
- 8 February 2011
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 74 (2), 223-227
- https://doi.org/10.1021/np100686a
Abstract
Atractylenolide III (1) is the major bioactive component of Atractylodes lancea. The aim of this study was to analyze the effect on the regulation of interleukin (IL)-6 secretion pathway caused by 1. This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. In addition, 1 inhibited histamine release in stimulated HMC-1 cells. In stimulated HMC-1 cells, 1 suppressed activation of p38 mitogen-activated protein kinase, C-Jun-N-terminal protein kinase, and nuclear factor-κB. In addition, 1 suppressed the activation of caspase-1 and the expression of receptor interacting protein-2. These results provide new insights that atractylenolide III (1) may control immunological reactions by regulating the cellular functions of IL-6 in mast cells.Keywords
This publication has 27 references indexed in Scilit:
- Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivoJournal of Pharmacy and Pharmacology, 2010
- Mast Cells, Histamine, and IL-6 Regulate the Selective Influx of Dendritic Cell Subsets into an Inflamed Lymph NodeThe Journal of Immunology, 2010
- Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013PLoS Pathogens, 2009
- The regulatory effect of SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l]benzenesulfonamide) on stem cell factor induced migration of mast cellsToxicology and Applied Pharmacology, 2007
- Alginic acid has anti‐anaphylactic effects and inhibits inflammatory cytokine expression via suppression of nuclear factor‐κB activationClinical & Experimental Allergy, 2006
- RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsNature, 2002
- Involvement of receptor-interacting protein 2 in innate and adaptive immune responsesNature, 2002
- The human mast cellJournal of Allergy and Clinical Immunology, 1997
- Critical protective role of mast cells in a model of acute septic peritonitisNature, 1996
- Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting EnzymeScience, 1995