Hepatitis C Virus Infection and Cardiomyopathies
- 4 February 2005
- journal article
- editorial
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 96 (2), 144-147
- https://doi.org/10.1161/01.res.0000156077.54903.67
Abstract
The importance of hepatitis C virus (HCV) infection has been recently noted in patients with cardiomyopathies. HCV RNAs were found in the hearts of patients with cardiomyopathies, and negative strands of HCV RNA were also detected in the hearts, suggesting that HCV replicates in myocardial tissues. In a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, HCV antibody was more frequently found in patients with cardiomyopathies than that found in volunteer blood donors in Japan. HCV antibody was detected in 5.4% seeking care in 5 academic hospitals. Various cardiac abnormalities were found, and arrhythmias was the most frequent. These observations suggest that HCV infection is an important cause of a variety of otherwise unexplained heart diseases. It is likely that antiviral agents such as interferons and ribavirin will be valuable in the treatment of cardiomyopathy due to HCV infection.Keywords
This publication has 19 references indexed in Scilit:
- Core Protein of Hepatitis C Virus Induces CardiomyopathyCirculation Research, 2005
- Hepatitis C Virus Core Selectively Suppresses Interleukin-12 Synthesis in Human Macrophages by Interfering with AP-1 ActivationOnline Journal of Public Health Informatics, 2004
- The Hepatitis C Virus Non-structural NS5A Protein Inhibits Activating Protein–1 Function by Perturbing Ras-ERK Pathway SignalingOnline Journal of Public Health Informatics, 2003
- Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan. Results From Nationwide Surveys.Circulation Journal, 2002
- Hepatitis C Virus Core Protein Induces Cell Proliferation and Activates ERK, JNK, and p38 MAP Kinases Together with the MAP Kinase Phosphatase MKP-1 in a HepG2 Tet-Off Cell LineVirology, 2002
- Cytoplasmic Localization Is Important for Transcription Factor Nuclear Factor-κB Activation by Hepatitis C Virus Core Protein through Its Amino Terminal RegionVirology, 2001
- The Prevalence of Hepatitis C Virus Infection in the United States, 1988 through 1994The New England Journal of Medicine, 1999
- Hypertension. Advances in diagnosis and treatment II. Methods of diagnosis and treatment 3. White coat hypertension.Nihon Naika Gakkai Zasshi, 1999
- A Clinical Trial of Immunosuppressive Therapy for MyocarditisThe New England Journal of Medicine, 1995
- An Autopsy Case of Hypertrophic Cardiomyopathy with Pathological Findings Suggesting Chronic Myocarditis.Japanese Heart Journal, 1994