Core Protein of Hepatitis C Virus Induces Cardiomyopathy
- 4 February 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 96 (2), 148-150
- https://doi.org/10.1161/01.res.0000154263.70223.13
Abstract
Hepatitis C virus (HCV) has been reported to be associated with cardiomyopathy. However, the mechanism of cardiomyopathy in chronic HCV infection is still unclear. Therefore, we investigate the development of cardiomyopathy in mice transgenic for the HCV-core gene. After the age of 12 months, mice developed cardiomyopathy that appeared as left ventricular dilatation, and systolic and diastolic dysfunction assessed by Doppler echocardiography. Histologically, hypertrophy of cardiomyocytes, cardiac fibrosis, disarray and scarcity of myofibrils, vacuolization and deformity of nuclei, myofibrillar lysis, streaming of Z-bands, and an increased number of bizarre-shaped mitochondria were found in HCV-core transgenic mice. These histological changes are just consistent with cardiomyopathy. In conclusion, the HCV-core protein directly plays an important role in the development of cardiomyopathy.Keywords
This publication has 10 references indexed in Scilit:
- Extrahepatic Manifestations of Hepatitis C InfectionThe American Journal of the Medical Sciences, 2003
- Alteration of Intrahepatic Cytokine Expression and AP-1 Activation in Transgenic Mice Expressing Hepatitis C Virus Core ProteinVirology, 2002
- Hepatitis C virus core particle detected by immunoelectron microscopy and optical rotation techniqueHepatology Research, 2001
- Angiotensin Blockade Inhibits Increased JNKs, AP-1 and NF- κ B DNA-binding Activities in Myocardial Infarcted RatsJournal of Molecular and Cellular Cardiology, 2001
- HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in miceJournal of Hepatology, 2000
- Mitochondrial DNA Mutations and Mitochondrial Abnormalities in Dilated CardiomyopathyThe American Journal of Pathology, 1998
- The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic miceNature Medicine, 1998
- Detection of Hepatitis C Virus RNA from the Heart of Patients with Hypertrophic CardiomyopathyBiochemical and Biophysical Research Communications, 1996
- High prevalence of thyroid autoantibodies in a prospective series of patients with chronic hepatitis C before interferon therapyHepatology, 1993
- Value of endomyocardial biopsy in infants, children and adolescents with dilated or hypertrophic cardiomyopathy and myocarditisJournal of the American College of Cardiology, 1988