Association of Glucocerebrosidase Mutations With Dementia With Lewy Bodies
Open Access
- 1 May 2009
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 66 (5), 578-583
- https://doi.org/10.1001/archneurol.2009.54
Abstract
Lewy body (LB) disorders include Parkinson disease (PD), dementia with LBs (DLB), and LB variant of Alzheimer disease (LBV-AD). They have in common pathologically the presence of aberrant intracellular α-synuclein aggregates (LBs and Lewy neurites). Clinically, these disorders tend to have symptoms of parkinsonism and dementia.1,2 It is common for Alzheimer disease (AD) and LB disorders to overlap; both may occur in the same brain (eg, LBV-AD).Keywords
This publication has 23 references indexed in Scilit:
- Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian populationNeurology, 2006
- Hematologically important mutations: Gaucher diseaseBlood Cells, Molecules, and Diseases, 2005
- Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technologyNucleic Acids Research, 2005
- Analysis of the glucocerebrosidase gene in Parkinson's diseaseMovement Disorders, 2005
- Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi JewsNew England Journal of Medicine, 2004
- Pilot association study of the β‐glucocerebrosidase N370S allele and Parkinson's disease in subjects of Jewish ethnicityMovement Disorders, 2004
- Glucocerebrosidase mutations in subjects with parkinsonismMolecular Genetics and Metabolism, 2004
- α-Synuclein and the Lewy body disordersCurrent Opinion in Neurology, 2001
- Glucocerebrosidase gene mutations in patients with type 2 Gaucher diseaseHuman Mutation, 2000
- The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)Neurology, 1991