Glucocerebrosidase gene mutations and Parkinson disease in the Norwegian population
- 14 February 2006
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 66 (3), 415-417
- https://doi.org/10.1212/01.wnl.0000196492.80676.7c
Abstract
An association between mutations in the glucocerebrosidase (GBA) gene and Parkinson disease (PD) was recently reported in Ashkenazi Jews. The authors screened a series of 311 Norwegian patients with PD and 474 controls for 2 common functional mutations of the GBA protein, N370S and L444P. Seven patients (2.3%) and 8 controls (1.7%) carried a mutant GBA allele (p = 0.58). This study does not indicate increased susceptibility to PD in GBA mutations carriers in Norway.Keywords
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