Gene therapy: can neural stem cells deliver?
- 1 January 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Neuroscience
- Vol. 7 (1), 75-84
- https://doi.org/10.1038/nrn1829
Abstract
Neural stem cells are a self-renewing population that generates the neurons and glia of the developing brain. They can be isolated, proliferated, genetically manipulated and differentiated in vitro and reintroduced into a developing, adult or pathologically altered CNS. Neural stem cells have been considered for use in cell replacement therapies in various neurodegenerative diseases, and an unexpected and potentially valuable characteristic of these cells has recently been revealed--they are highly migratory and seem to be attracted to areas of brain pathology such as ischaemic and neoplastic lesions. Here, we speculate on the ways in which neural stem cells might be exploited as delivery vehicles for gene therapy in the CNS.Keywords
This publication has 101 references indexed in Scilit:
- Common mechanisms of nerve and blood vessel wiringNature, 2005
- GDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALSHuman Gene Therapy, 2005
- Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson’s diseaseThe International Journal of Biochemistry & Cell Biology, 2004
- Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosisNature, 2003
- Slit and glypican‐1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brainGlia, 2003
- Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitisGlia, 2002
- Astroglia induce neurogenesis from adult neural stem cellsNature, 2002
- Mammalian Neural Stem CellsScience, 2000
- Lumbar transplants of immortalized serotonergic neurons alleviate chronic neuropathic painPain, 1997
- Ex VivoGene Transfer of Brain-derived Neurotrophic Factor to the Intact Rat Forebrain: Neurotrophic Effects on Cholinergic NeuronsEuropean Journal of Neuroscience, 1996