Regulatory T cells in autoimmune disease
Top Cited Papers
- 1 July 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 19 (7), 665-673
- https://doi.org/10.1038/s41590-018-0120-4
Abstract
In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded considerably. Key observations have challenged the traditional definition of Treg cells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic strategies that improve disease outcome. This Review summarizes the newer concepts of Treg cell instability, Treg cell plasticity and tissue-specific Treg cells, and their relationship to autoimmunity. Those three main concepts have changed the understanding of Treg cell biology: how they interact with other immune and nonimmune cells; their functions in specific tissues; and the implications of this for the pathogenesis of autoimmune diseases.This publication has 133 references indexed in Scilit:
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