Marihuana: Studies on the Disposition and Metabolism of Delta-9-Tetrahydrocannabinol in Man
- 18 December 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3964), 1320-1322
- https://doi.org/10.1126/science.170.3964.1320
Abstract
Δ9-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t1/2 = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Δ9-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days.Keywords
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