Metabolite of (—)- trans -Δ 8 -Tetrahydrocannabinol: Identification and Synthesis
- 15 May 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3933), 844-845
- https://doi.org/10.1126/science.168.3933.844
Abstract
The major metabolite of (—)-trans-Δ8-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Δ8-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Δ8-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Δ8- and Δ9-tetrahydrocannabinol.Keywords
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