Immunomodulatory Activity ofChlorophytum borivilianumSant. F

Abstract

Chlorophytum borivilianumSantapau & Fernandes (Liliaceae) is a very popular herb in traditional Indian medicine and constitute a group of herbs used as ‘Rasayan’ or adaptogen. Ethanolic extract of the roots and its sapogenin were evaluated for their immunomodulatory activity. Effect of azathioprine-induced myelosuppresion and administration of extracts on hematological and serological parameters was determined. Administration of extracts greatly improved survival againstCandida albicansinfection. An increase in delayed-type hypersensitivity response (DTH), % neutrophil adhesion andin vivophagocytosis by carbon clearance method was observed after treatment with extracts. Immunostimulant activity of ethanolic extract was more pronounced as compared to sapogenins. The results, thus justifies the traditional use ofC. borivilianumas a rasayana drug.