Brahmi rasayanaImproves Learning and Memory in Mice
Open Access
- 1 January 2006
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 3 (1), 79-85
- https://doi.org/10.1093/ecam/nek014
Abstract
Cure of cognitive disorders such as amnesia, attention deficit and Alzheimer's disease is still a nightmare in the field of medicine. Nootropic agents such as piracetam, aniracetam and choline esterase inhibitors like Donepezil® are being used to improve memory, mood and behavior, but the resulting side effects associated with these agents have made their use limited. The present study was undertaken to assess the potential ofBrahmi rasayana(BR) as a memory enhancer. BR (100 and 200 mg kg−1 p.o.) was administered for eight successive days to both young and aged mice. Elevated plus maze and passive-avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg kg−1 i.p.) was used to induce amnesia in mice. The effect of BR on whole brain AChE activity was also assessed. Piracetam (200 mg kg−1 i.p.) was used as a standard nootropic agent. BR significantly improved learning and memory in young mice and reversed the amnesia induced by both scopolamine (0.4 mg kg−1 i.p.) and natural aging. BR significantly decreased whole brain acetyl cholinesterase activity. BR might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly.Keywords
This publication has 29 references indexed in Scilit:
- Sensitivity of fungi isolated from onychomycosis to Eugenia cariophyllata essential oil and eugenolFitoterapia, 2005
- Improvement of Mouse Memory by Myristica fragrans SeedsJournal of Medicinal Food, 2004
- Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in miceToxicon, 2004
- Immunotoxicological effects of piperine in miceToxicology, 2004
- Cinnamon Improves Glucose and Lipids of People With Type 2 DiabetesDiabetes Care, 2003
- Pro‐healing effect of Cinnamomum zeylanicum barkPhytotherapy Research, 2003
- Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brainPhytotherapy Research, 2002
- Chronic Effects of Brahmi (Bacopa monnieri) on Human MemoryNeuropsychopharmacology, 2002
- Piracetam Improves Cognitive Performance by Restoring Neurochemical Deficits of the Aged Rat BrainPharmacopsychiatry, 1999
- PHARMACOLOGICAL STUDIES OF CARDAMOM OIL IN ANIMALSPharmacological Research, 1996