The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance
Top Cited Papers
- 19 March 2008
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 222 (1), 155-161
- https://doi.org/10.1111/j.1600-065x.2008.00607.x
Abstract
Summary: An intrinsic (oncogene‐driven) pathway and an extrinsic (microenvironment‐driven) pathway connect inflammatory reactions and cancer. M2‐polarized tumor‐associated macrophages and the related myeloid‐derived suppressor cells are key prototypic components of smoldering inflammation driving neoplastic progression. However, mononuclear phagocytes can exert anti‐tumor activity by killing tumor cells and eliciting tissue disruptive reactions (M1), a likely scenario in the early phases of carcinogenesis of immunogenic tumors and following therapeutic intervention. Shifting the macrophage balance represents a viable therapeutic target. Herein, the ‘macrophage balance’ is discussed in the context of the apparent paradox of tumor promotion by innate immunity‐driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses.Keywords
This publication has 52 references indexed in Scilit:
- A High Tumor-Associated Macrophage Content Predicts Favorable Outcome in Follicular Lymphoma Patients Treated with Rituximab and Cyclophosphamide-Doxorubicin-Vincristine-PrednisoneClinical Cancer Research, 2007
- Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapyNature Medicine, 2007
- Altered macrophage differentiation and immune dysfunction in tumor developmentJCI Insight, 2007
- Regulation of immune responses by L-arginine metabolismNature Reviews Immunology, 2005
- A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast CancerThe New England Journal of Medicine, 2004
- Tumour-educated macrophages promote tumour progression and metastasisNature Reviews Cancer, 2004
- Alternative activation of macrophagesNature Reviews Immunology, 2003
- Inflammation and cancerNature, 2002
- Endothelin-1 Induces Vascular Endothelial Growth Factor by Increasing Hypoxia-inducible Factor-1α in Ovarian Carcinoma CellsOnline Journal of Public Health Informatics, 2002
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 1996