The management of cervical dystonia
- 26 January 2007
- journal article
- review article
- Published by Informa UK Limited in Expert Opinion on Pharmacotherapy
- Vol. 8 (2), 129-140
- https://doi.org/10.1517/14656566.8.2.129
Abstract
Cervical dystonia (CD), also known as ‘spasmodic torticollis’, is the most common form of adult-onset focal dystonia. It is a chronic disorder for which there is no curative treatment. Proposed interventions only have a symptomatic effect that is directed at controlling the intensity of the dystonic contractions and their associated symptoms. Both serotypes of botulinum toxin (BtA and BtB) have shown efficacy for the treatment of CD, and they constitute the first-line therapy for CD. BtB constitutes the best medical treatment for secondary failures to BtA. The efficacy of all other proposed medications, including anticholinergics, should be considered unknown due to the lack of good-quality trials. This lack of evidence applies also to all physical rehabilitation treatments. Although the authors have concluded that all surgical procedures for CD should still be considered investigational, the best data supporting benefit of surgery comes from case series of selective peripheral denervation and pallidal deep brain stimulation.Keywords
This publication has 82 references indexed in Scilit:
- Secondary nonresponsiveness to botulinum toxin A in cervical dystonia: The role of electromyogram‐guided injections, botulinum toxin A antibody assay, and the extensor digitorum brevis testMovement Disorders, 2006
- SV2 Is the Protein Receptor for Botulinum Neurotoxin AScience, 2006
- Retrospective evaluation of the dose of dysport and BOTOX in the management of cervical dystonia and blepharospasm: The REAL DOSE studyMovement Disorders, 2005
- Complex mechanisms of sensory tricks in cervical dystoniaMovement Disorders, 2003
- Long‐term follow‐up of cervical dystonia patients treated with botulinum toxin AMovement Disorders, 2003
- Cervical DystoniaDrugs, 2001
- Selective peripheral denervation for spasmodic torticollis: Surgical technique, results, and observations in 260 casesSurgical Neurology, 1993
- Baclofen in the Treatment of DystoniaClinical Neuropharmacology, 1992
- Baclofen in the treatment of idiopathic dystonia in childrenMovement Disorders, 1992
- Treatment of hyperkinetic movement disorders with tetrabenazine: A double‐blind crossover studyAnnals of Neurology, 1982