Long‐term follow‐up of cervical dystonia patients treated with botulinum toxin A
- 14 November 2003
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 19 (3), 303-308
- https://doi.org/10.1002/mds.10659
Abstract
We followed the course in 100 consecutive patients with cervical dystonia (CD) after they were initially treated with botulinum toxin (BTX) in the form of Dysport 10 to 12 years ago. A total of 4 patients had died, and 6 were lost to follow‐up. Of the remaining 90 patients, 57 (63%) were still treated with BTX. In the patients treated at one centre over the whole period with Dysport, mean dose used during each treatment session was 833 (SD ± 339) units Dysport with a cumulative dose of 20,943 (SD ± 9462) units Dysport over a mean of 26.8 (SD ± 8.6) treatment cycles. Secondary nonresponse was detected in 3 of the 90 patients. During follow‐up, 12 patients developed blepharospasm, 13 oromandibular dystonia, and 17 patients writer's cramp. We conclude that BTX remains effective and safe for approximately 60% of CD patients for more than 10 years. © 2003 Movement Disorder SocietyThis publication has 27 references indexed in Scilit:
- Impact of cervical dystonia on quality of lifeMovement Disorders, 2002
- What are the determinants of quality of life in people with cervical dystonia?Journal of Neurology, Neurosurgery & Psychiatry, 2002
- Health related quality of life is improved by botulinum neurotoxin type A in long term treated patients with focal dystoniaJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Longitudinal experience with botulinum toxin injections for treatment of blepharospasm and cervical dystoniaNeurology, 1993
- Cervical dystoniaNeurology, 1991
- Double‐blind, placebo‐controlled trial of botulinum toxin injections for the treatment of spasmodic torticollisNeurology, 1990
- Natural History of Adult-Onset Idiopathic TorticollisArchives of Neurology, 1990
- The clinical course of spasmodic torticollisNeurology, 1988
- Botulinum A toxin for cranial‐cervical dystoniaNeurology, 1987
- A Pilot Study on the Use of Botulinum Toxin in Spasmodic TorticollisCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1985