Definition, course, and outcome of mild cognitive impairment

Abstract
Mild Cognitive Impairment (MCI) is a term which can be applied to a boundary area between dementia and normal aging. Criteria which reliably describe persons falling in this range of the cognitive continuum can be defined. These persons are at very high risk for developing dementia. Biologic and cognitive parameters including Apolipoprotein E genotype help to differentiate MCI persons who will progress to dementia in 2-4 years from those who will remain free from dementia over this interval.