Surgery Results in Exaggerated and Persistent Cognitive Decline in a Rat Model of the Metabolic Syndrome
Open Access
- 1 May 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 118 (5), 1098-1105
- https://doi.org/10.1097/aln.0b013e318286d0c9
Abstract
Background: Postoperative cognitive decline can be reproduced in animal models. In a well-validated rat model of the Metabolic Syndrome, we sought to investigate whether surgery induced a more severe and persistent form of cognitive decline similar to that noted in preliminary clinical studies. Methods: In rats that had been selectively bred for low and high exercise endurance, the low capacity runners (LCR) exhibited features of Metabolic Syndrome (obesity, dyslipidemia, insulin resistance, and hypertension). Tibial fracture surgery was performed under isoflurane anesthesia in LCR and high capacity runner (HCR) rats and cognitive function was assessed postoperatively in a trace-fear conditioning paradigm and Morris Water Maze; non-operated rats were exposed to anesthesia and analgesia (sham). Group sizes were n = 6. Results: On postoperative D7, LCR rats had shorter freezing times than postoperative HCR rats. Five months postoperatively, LCR rats had a flatter learning trajectory and took longer to locate the submerged platform than postoperative HCR rats; dwell-time in the target quadrant in a probe trial was shorter in the postoperative LCR compared to HCR rats. LCR and HCR sham rats did not differ in any test. Conclusion: Postoperatively, LCR rats diverged from HCR rats exhibiting a greater decline in memory, acutely, with persistent learning and memory decline, remotely; this could not be attributed to changes in locomotor or swimming performance. This Metabolic Syndrome animal model of surgery-induced cognitive decline corroborates, with high fidelity, preliminary findings of postoperative cognitive dysfunction in Metabolic Syndrome patients.Keywords
This publication has 36 references indexed in Scilit:
- Cognitive and Neurologic Outcomes after Coronary-Artery Bypass SurgeryThe New England Journal of Medicine, 2012
- Postoperative cognitive dysfunction after noncardiac surgery: effects of metabolic syndromeJournal of Anesthesia, 2011
- Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive declineProceedings of the National Academy of Sciences of the United States of America, 2010
- Adiponectin receptor binding proteins – recent advances in elucidating adiponectin signalling pathwaysFEBS Letters, 2010
- Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacityHormones and Behavior, 2010
- Metabolic syndrome is an independent risk factor for stroke and acute renal failure after coronary artery bypass graftingThe Journal of Thoracic and Cardiovascular Surgery, 2009
- Long-term Consequences of Postoperative Cognitive DysfunctionAnesthesiology, 2009
- Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistanceAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Epistasis and the release of genetic variation during long-term selectionNature Genetics, 2006
- The Cost of Delirium in the Surgical PatientPsychosomatics, 2001