Adiponectin receptor binding proteins – recent advances in elucidating adiponectin signalling pathways
- 27 September 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (20), 4280-4286
- https://doi.org/10.1016/j.febslet.2010.09.035
Abstract
Adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed. Clathrin-dependent endocytosis of AdipoR1 and adiponectin has been demonstrated to modulate adiponectin bioactivity. Recently, APPL1 has been identified as an AdipoR1 and AdipoR2 binding protein. Furthermore, activated protein kinase C1, endoplasmic reticulum protein 46 and protein kinase CK2β subunit form a complex with AdipoR1. This review summarizes recent studies exploiting heterologous expression of adiponectin receptors in yeast, and the type and function of the recently described adiponectin receptor associated proteins.Keywords
Funding Information
- Faculty of Medicine of the University of Regensburg
This publication has 63 references indexed in Scilit:
- Adiponectin Levels and Risk of Type 2 DiabetesJAMA, 2009
- Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectinThe FASEB Journal, 2008
- Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serumDiabetologia, 2007
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeJCI Insight, 2006
- Mechanisms of Disease: adipocytokines and visceral adipose tissue—emerging role in nonalcoholic fatty liver diseaseNature Clinical Practice Gastroenterology & Hepatology, 2005
- Adiponectin, the missing link in insulin resistance and obesityClinical Nutrition, 2004
- Impaired Multimerization of Human Adiponectin Mutants Associated with DiabetesJournal of Biological Chemistry, 2003
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsNature, 2003
- Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in miceProceedings of the National Academy of Sciences of the United States of America, 2001
- Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in ObesityBiochemical and Biophysical Research Communications, 1999