The prevalence of rheumatoid factor isotypes and anti‐cyclic citrullinated peptides in Malaysian rheumatoid arthritis patients
- 26 October 2010
- journal article
- Published by Wiley in International Journal of Rheumatic Diseases
- Vol. 14 (1), 12-17
- https://doi.org/10.1111/j.1756-185x.2010.01573.x
Abstract
The purpose of this study is to compare the prevalence of rheumatoid factor (RF) isotypes and second generation anti-cyclic citrullinated peptides (anti-CCP) in Malaysian rheumatoid arthritis (RA) patients. In this cross-sectional study, 147 established RA patients from three ethnic groups were recruited from a major rheumatology clinic in Malaysia. Enzyme-linked immunosorbent assays (ELISA) for serum RF isotypes IgA, IgG and IgM as well as second-generation anti-CCP were performed and the prevalence of each auto-antibody was compared in the three ethnic groups. The anti-CCP was the most prevalent auto-antibody in each of the ethnic groups, followed closely by RF IgM and RF IgG. Rheumatoid factor IgA was the least prevalent across all three ethnic groups. The anti-CCP-RF IgM combination provided the best test sensitivity. Seroprevalence of anti-CCP was strongly associated with the presence of each of the RF isotypes. The seroprevalence of RF and anti-CCP did not increase or decrease with advancing age, age at onset and disease duration. When used alone, anti-CCP provides a diagnostic advantage over RF IgM on the basis of test sensitivity. Considering the high cost of the anti-CCP assay, step-wise serum testing with IgM RF followed by anti-CCP may provide a more economically sensible option to optimize test sensitivity for RA.Keywords
This publication has 20 references indexed in Scilit:
- Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoantibody systemsArthritis Research & Therapy, 2009
- On The Occurrence Of A Factor In Human Serum Activating The Specific Agglutintion of Sheep Blood CorpusclesAPMIS, 2007
- Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcomeRheumatology, 2005
- A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2005
- Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2004
- Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donorsArthritis & Rheumatism, 2004
- Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisArthritis & Rheumatism, 2003
- Relationship among the HLA–DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritisArthritis Care & Research, 2002
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- AN UNUSUAL PROTEIN COMPONENT OF HIGH MOLECULAR WEIGHT IN THE SERUM OF CERTAIN PATIENTS WITH RHEUMATOID ARTHRITISThe Journal of Experimental Medicine, 1957